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小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体)

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Mouse LTA4H cDNA Clone产品信息
NCBI注册码:NM_008517.2
参考序列ORF长度:1836bp
cDNA基因描述:Full length Clone DNA of Mus musculus leukotriene A4 hydrolase.
分子别称:Lta4h
分子种属:Mouse
载体:pCMV3-untagged
质粒:
限制性酶切位点:
Tag序列:
序列信息:
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicilin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体) on other vectors
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签MG50268-ACG2070
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签MG50268-ACR2070
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-GFPSpark 标签MG50268-ANG2070
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-OFPSpark 标签MG50268-ANR2070
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-Flag 标签MG50268-CF1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-His 标签MG50268-CH1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-Myc 标签MG50268-CM1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-HA 标签MG50268-CY1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA(克隆载体)MG50268-M920
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-Flag 标签MG50268-NF1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-His 标签MG50268-NH1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-Myc 标签MG50268-NM1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), N-HA 标签MG50268-NY1890
小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体)MG50268-UT1890
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研究背景

Mouse leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

参考资料
  • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
  • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
  • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
  • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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    货号: MG50268-UT
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    库存2-3 weeks
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