|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||MG51398-ACG|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||MG51398-ACR|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||MG51398-CF|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-His 标签||MG51398-CH|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||MG51398-CM|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), C-HA 标签||MG51398-CY|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||MG51398-NF|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), N-His 标签||MG51398-NH|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||MG51398-NM|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体), N-HA 标签||MG51398-NY|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA(克隆载体)||MG51398-U|
|小鼠 MAG/GMA/Siglec-4 基因ORF全长cDNA克隆(表达载体)||MG51398-UT|
The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.