( We provide with MCAM qPCR primers for gene expression analysis, MP200766 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||MG50794-ACG|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||MG50794-ACR|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||MG50794-CF|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-His 标签||MG50794-CH|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||MG50794-CM|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), C-HA 标签||MG50794-CY|
|小鼠 CD146/MCAM 基因ORF全长cDNA(克隆载体)||MG50794-G|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||MG50794-NF|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), N-His 标签||MG50794-NH|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||MG50794-NM|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体), N-HA 标签||MG50794-NY|
|小鼠 CD146/MCAM 基因ORF全长cDNA克隆(表达载体)||MG50794-UT|
The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.