Peroxiredoxin 1 cDNA ORF Clone, Mouse, N-HA tag

Cat: MG50552-NY
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Peroxiredoxin 1 cDNA ORF Clone, Mouse, N-HA tag 基本信息
基因
种属
Mouse
NCBI 参考序列号
参考序列ORF长度
600 bp
描述
Full length Clone DNA of Mouse peroxiredoxin 1 with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-N-HA
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Peroxiredoxin 1 cDNA ORF Clone, Mouse, N-HA tag Alternative Names
MSP23 cDNA ORF Clone, Mouse;NkefA cDNA ORF Clone, Mouse;OSF-3 cDNA ORF Clone, Mouse;OSF3 cDNA ORF Clone, Mouse;PAG cDNA ORF Clone, Mouse;Paga cDNA ORF Clone, Mouse;PrdxI cDNA ORF Clone, Mouse;prx1 cDNA ORF Clone, Mouse;PrxI cDNA ORF Clone, Mouse;Tdpx2 cDNA ORF Clone, Mouse;TDX2 cDNA ORF Clone, Mouse;TPxA cDNA ORF Clone, Mouse
Peroxiredoxin 1 Background Information

Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

Full Name
peroxiredoxin 1
References
  • Neumann, CA. et al., 2003, Nature 424 (6948): 561-5
  • Gisin, J. et al., 2005, J Clin Pathol. 58 (11): 1229-31.
  • Hoshino, I. et al., 2007, Oncol Rep. 18 (4): 867-71.
  • Cao, J. et al., 2009, EMBO J. 28 (10): 1505-17.
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