PSMA cDNA ORF Clone, Mouse, N-Myc tag

Cat: MG50214-NM
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PSMA cDNA ORF Clone, Mouse, N-Myc tag 基本信息
基因
种属
Mouse
NCBI 参考序列号
参考序列ORF长度
2259 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1842G/A, 2345C/T, 2347T/A not causing the amino acid variation.
描述
Full length Clone DNA of Mouse folate hydrolase with N terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-SP-N-Myc
限制性酶切位点
HindIII + XbaI (6kb + 2.35kb)
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
PSMA cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

PSMA cDNA ORF Clone, Mouse, N-Myc tag Validated Images
Human HER2/ERBB2 Gene Plasmid Map 5632
PSMA cDNA ORF Clone, Mouse, N-Myc tag Alternative Names
GCP2 cDNA ORF Clone, Mouse;mopsm cDNA ORF Clone, Mouse
PSMA Background Information

Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type I I membrane protein which belongs to the peptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
folate hydrolase (prostate-specific membrane antigen) 1
References
  • Israeli R.S., et al.,(1993), Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53:227-230.
  • Su S.L., et al., (1995), Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.Cancer Res. 55:1441-1443.
  • O'Keefe D.S., et al.,(1998), Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.Biochim. Biophys. Acta 1443:113-127.
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