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小鼠 Raf-1/RAF1 基因ORF全长cDNA克隆(表达载体)

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    小鼠 RAF1 cDNA Clone产品信息
    NCBI注册码:NM_029780.3
    参考序列ORF长度:1947bp
    cDNA基因描述:Full length Clone DNA of Mus musculus v-raf-leukemia viral oncogene 1.
    分子别称:Apn, Cd13, Lap-1, Lap1, p150
    分子种属:Mouse
    载体:pCMV3-untagged
    质粒:
    限制性酶切位点:
    Tag序列:
    序列信息:
    测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with RAF1 qPCR primers for gene expression analysis, MP200311 )
    启动子:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    抗生素(大肠杆菌):Ampicillin
    抗生素(哺乳动物细胞):Hygromycin
    运输方式:Each tube contains lyophilized plasmid.
    储存方法:The lyophilized plasmid can be stored at room temperature for three months.
    Product nameProduct name
    研究背景

    RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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    货号: MG50287-UT
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    Datasheet & Documentation

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