快速订购

小鼠 S100A1 基因ORF全长cDNA克隆(表达载体)

产品数据评论相关产品实验方法
小鼠 S100A1 cDNA Clone产品信息
NCBI注册码:NM_011309.3
参考序列ORF长度:285bp
cDNA基因描述:Full length Clone DNA of Mus musculus S100 calcium binding protein A1.
分子别称:S100, S100a, AI266795, S100a1
分子种属:Mouse
载体:pCMV3-untagged
质粒:pCMV3-mS100A1
限制性酶切位点:KpnI + XbaI(6.1kb+0.29kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with S100A1 qPCR primers for gene expression analysis, MP200291 )
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Product nameProduct name
研究背景

S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

参考资料
  • Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257.
  • Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894
  • Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233.
  • Schafer, W.E. et al., 1995, Genomics. 25: 638-643.
  • Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.
  • Size / Price
    货号: MG50266-UT
    目录价: 
    单价:      (You Save: )
    规格:
    数量:+-
    库存In Stock
    加入购物车大包装查询
    Contact Us
    产品图片
    • other Green fluorescent protein / GFP Gene Plasmid Map 5613
      产品数据可能随批次变化,最新数据请详见随货说明书。
      请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”