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小鼠 Ly108/SLAMF6 基因ORF全长cDNA克隆(表达载体)

  • other Green fluorescent protein / GFP Gene Plasmid Map 5613
产品数据评论相关产品实验方法
小鼠 SLAMF6 cDNA Clone产品信息
NCBI注册码:NM_030710.2
参考序列ORF长度:996bp
cDNA基因描述:Full length Clone DNA of Mus musculus SLAM family member 6.
分子别称:KAL1, NTBA, KAL1b, Ly108, NTB-A, SF2000, Slamf6
分子种属:Mouse
载体:pCMV3-untagged
质粒:pCMV3-mSLAMF6
限制性酶切位点:KpnI + XbaI(6.1kb+1kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence except for the point mutations: 433C/T,756T/A not causing the amino acid variation.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with SLAMF6 qPCR primers for gene expression analysis, MP200299 )
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Product nameProduct name
研究背景

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

参考资料
  • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
  • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
  • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
  • Claus M. et al., 2007, Front Biosci. 13: 956-65.
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    货号: MG50275-UT
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    Datasheet & Documentation

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