N Cadherin (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All N Cadherin reagents are produced in house and quality controlled, including 11 N Cadherin Antibody, 28 N Cadherin Gene, 4 N Cadherin Lysate, 4 N Cadherin Protein, 3 N Cadherin qPCR. All N Cadherin reagents are ready to use.

N Cadherin Protein (4)

N Cadherin Antibody (11)

N Cadherin cDNA Clone (28)

NM_001792.3

克隆载体 cDNA 产品

In lentiviral vector

NM_007664.4

克隆载体 cDNA 产品

In lentiviral vector

NM_031333.1

克隆载体 cDNA 产品

In lentiviral vector

N Cadherin Lysate (4)

N Cadherin 分子背景

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 2-1 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.

N Cadherin 参考文献

  • Jones M, et al. (2002) N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Arterioscler Thromb Vasc Biol. 22(12): 1972-7.
  • Nagi C, et al. (2005) N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3): 225-35.
  • Schrick C, et al. (2007) N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron. 55(5): 786-98.
  • Li K, et al. (2010) Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma. Cancer Invest. 28(5): 479-86.