CXCL7 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All CXCL7 reagents are produced in house and quality controlled, including 5 CXCL7 Antibody, 52 CXCL7 Gene, 1 CXCL7 IP Kit, 2 CXCL7 Lysate, 7 CXCL7 Protein, 3 CXCL7 qPCR. All CXCL7 reagents are ready to use.

CXCL7 Protein (7)

CXCL7 Antibody (5)

CXCL7 cDNA Clone (52)

NM_002704.2

克隆载体 cDNA 产品

In lentiviral vector

NM_023785.2

克隆载体 cDNA 产品

In lentiviral vector

NM_153721.1

克隆载体 cDNA 产品

In lentiviral vector

XM_001102705.2

克隆载体 cDNA 产品

In lentiviral vector

CXCL7 Lysate (2)

CXCL7 分子背景

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

CXCL7 参考文献

  • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
  • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
  • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.