Anti-NRG1 Beta 1 Antibody

1/1
Price:
Size:
Number:

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-NRG1 Beta 1 Antibody
经验证的应用
WB
交叉反应
Reacts with: Human
特异性
Human Neuregulin-1
No cross-reactivity in WB with
Human NRG1-alpha
免疫原
A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1.
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG2b Clone #03
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal 抗体) 图片

Anti-NRG1-beta 1 mouse monoclonal antibody at 1:500

Lane A: Human NRG1-beta1 (11609-H01H2) (100ng)

Lane B: Human NRG1-alpha (13499-H02H) (100ng)

Secondary

Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Performed under reducing conditions.

Anti-NRG1 Beta 1 Antibody: 别称

Anti-ARIA Antibody; Anti-GGF Antibody; Anti-GGF2 Antibody; Anti-HGL Antibody; Anti-HRG Antibody; Anti-HRG1 Antibody; Anti-HRGA Antibody; Anti-MST131 Antibody; Anti-MSTP131 Antibody; Anti-NDF Antibody; Anti-Neuregulin 1 Antibody; Anti-NRG1-IT2 Antibody; Anti-SMDF Antibody

Neuregulin-1 背景信息

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
全称
neuregulin 1
参考文献
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后