Neuropilin-1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All Neuropilin-1 reagents are produced in house and quality controlled, including 6 Neuropilin-1 Antibody, 51 Neuropilin-1 Gene, 5 Neuropilin-1 Lysate, 5 Neuropilin-1 Protein, 3 Neuropilin-1 qPCR. All Neuropilin-1 reagents are ready to use.

Recombinant Neuropilin-1 proteins are expressed by HEK293 Cells with fusion tags as C-cleavage, C-human IgG1-Fc, C-His.

Neuropilin-1antibodies are validated with different applications, which are FCM, ELISA, IHC-P.

Neuropilin-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Neuropilin-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Neuropilin-1 Protein (5)

Species

Neuropilin-1 Protein, Cynomolgus, Recombinant (His Tag)

90297-C08H

Expression host: HEK293 Cells

Cynomolgus Neuropilin-1/NRP1/CD304 Protein 12947

Neuropilin-1 Protein, Cynomolgus, Recombinant (Fc Tag)

90297-C02H

Expression host: HEK293 Cells

Cynomolgus Neuropilin-1/NRP1/CD304 Protein 12946

Neuropilin-1 Protein, Human, Recombinant (His Tag)

10011-H08H

Expression host: HEK293 Cells

Human Neuropilin-1/NRP1/CD304 Protein 8304

Neuropilin-1 Protein, Human, Recombinant (Fc Tag)

10011-H02H

Expression host: HEK293 Cells

Human Neuropilin-1/NRP1/CD304 Protein 8303

Neuropilin-1 Protein, Cynomolgus, Recombinant

90297-CCCH

Expression host: HEK293 Cells

Cynomolgus Neuropilin-1/NRP1/CD304 Protein 12948
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Neuropilin-1 Antibody (6)

Application Clonality
Host

Anti-Neuropilin-1 Antibody (APC)

10011-MM01-A

Application: FCM

Clonality: MAb

Human Neuropilin-1/NRP1/CD304 Flow Cytometry (FC) 5080

Anti-Neuropilin-1 Antibody

10011-RP01

Application: ELISA

Clonality: PAb

Anti-Neuropilin-1 Antibody

10011-MM01

Application: FCM

Clonality: MAb

Human Neuropilin-1/NRP1/CD304 Flow Cytometry (FC) 5079

Anti-Neuropilin-1 Antibody

10011-R042

Application: ELISA,IHC-P

Clonality: MAb

Human Neuropilin-1/NRP1/CD304 Immunohistochemistry(IHC) 3841

Anti-Neuropilin-1 Antibody (PE)

10011-MM01-P

Application: FCM

Clonality: MAb

Human Neuropilin-1/NRP1/CD304 Flow Cytometry (FC) 5080

Anti-Neuropilin-1 Antibody

10011-T16

Application: ELISA

Clonality: PAb

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Neuropilin-1 cDNA Clone (51)

Mouse
Human
Rat

Neuropilin-1 qPCR Primer (3)

Neuropilin-1 Lysate (5)

Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.

Protein
Antibody
Gene
qPCR
Lysate
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