PCSK9 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All PCSK9 reagents are produced in house and quality controlled, including 20 PCSK9 Antibody, 5 PCSK9 ELISA, 39 PCSK9 Gene, 14 PCSK9 Lysate, 15 PCSK9 Protein, 3 PCSK9 qPCR. All PCSK9 reagents are ready to use.

PCSK9 Protein (15)

PCSK9 Antibody (20)

PCSK9 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(5)

PCSK9 cDNA Clone (39)

NM_174936.3

克隆载体 cDNA 产品

In lentiviral vector

NM_153565.2

克隆载体 cDNA 产品

In lentiviral vector

NM_199253.2

克隆载体 cDNA 产品

In lentiviral vector

PCSK9 Lysate (14)

PCSK9 分子背景

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

References

PCSK9 参考文献

  • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
  • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
  • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
  • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.