( We provide with AKR1A1 qPCR primers for gene expression analysis, RP300750 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||RG80786-ACG|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||RG80786-ACR|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-GFPSpark 标签||RG80786-ANG|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-OFPSpark 标签||RG80786-ANR|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||RG80786-CF|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-His 标签||RG80786-CH|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||RG80786-CM|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), C-HA 标签||RG80786-CY|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||RG80786-NF|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-His 标签||RG80786-NH|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||RG80786-NM|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体), N-HA 标签||RG80786-NY|
|大鼠 AKR1A1 基因ORF全长cDNA(克隆载体)||RG80786-U|
|大鼠 AKR1A1 基因ORF全长cDNA克隆(表达载体)||RG80786-UT|
Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.