CD59 cDNA ORF Clone, Rat, N-His tag

Cat: RG80299-NH
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CD59 cDNA ORF Clone, Rat, N-His tag 基本信息
基因
种属
Rat
NCBI 参考序列号
参考序列ORF长度
381 bp
描述
Full length Clone DNA of Rat CD59 molecule, complement regulatory protein with N terminal His tag.
质粒
启动子
Enhanced CMV promoter
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD59 cDNA ORF Clone, Rat, N-His tag Alternative Names
CD59 cDNA ORF Clone, Rat
CD59 Background Information

CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Full Name
CD59 molecule
References
  • Fletcher CM. et al., 1994, Structure. 2: 185-99.
  • Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
  • Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
  • Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
  • Picariello G. et al., 2008, Proteomics 8: 3833-47.
  • Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
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    CD59 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CD59 cDNA ORF Clone in Cloning Vector, Rat RG80299-G
    CD59 cDNA ORF Clone, Rat, untagged RG80299-UT
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    CD59 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80299-ACG
    CD59 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80299-ACR
    CD59 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80299-CF
    CD59 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80299-NF
    CD59 cDNA ORF Clone, Rat, C-His tag RG80299-CH
    CD59 cDNA ORF Clone, Rat, C-HA tag RG80299-CY
    CD59 cDNA ORF Clone, Rat, N-HA tag RG80299-NY
    CD59 cDNA ORF Clone, Rat, C-Myc tag RG80299-CM
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    CD59 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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