CD6 cDNA ORF Clone, Rat, C-HA tag

Cat: RG80311-CY

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CD6 cDNA ORF Clone, Rat, C-HA tag 基本信息

基因

种属
Rat
NCBI 参考序列号
参考序列ORF长度
1998 bp
描述
Full length Clone DNA of Rat Cd6 molecule with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD6 Background Information

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Full Name
CD6 molecule
References
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
  • CD6 cDNA ORF Clone, Rat, Related Products

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    CD6 cDNA ORF Clone in Cloning Vector, Rat RG80311-G
    CD6 cDNA ORF Clone, Rat, untagged RG80311-UT
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    CD6 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80311-CF
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    CD6 cDNA ORF Clone, Rat, C-His tag RG80311-CH
    CD6 cDNA ORF Clone, Rat, N-His tag RG80311-NH
    CD6 cDNA ORF Clone, Rat, N-HA tag RG80311-NY
    CD6 cDNA ORF Clone, Rat, C-Myc tag RG80311-CM
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    CD6 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CD6 cDNA ORF Clone in Cloning Vector, Mouse MG50711-G
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    CD6 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CD6 cDNA ORF Clone in Cloning Vector, Human HG17051-G
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    CD6 cDNA ORF Clone, Human, C-OFPSpark® tag HG17051-ACR
    CD6 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG17051-CF
    CD6 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG17051-NF
    CD6 cDNA ORF Clone, Human, C-His tag HG17051-CH
    CD6 cDNA ORF Clone, Human, N-His tag HG17051-NH
    CD6 cDNA ORF Clone, Human, C-HA tag HG17051-CY
    CD6 cDNA ORF Clone, Human, N-HA tag HG17051-NY
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