( We provide with CD68 qPCR primers for gene expression analysis, RP300283 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||RG80307-ACG|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||RG80307-ACR|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||RG80307-CF|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-His 标签||RG80307-CH|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||RG80307-CM|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), C-HA 标签||RG80307-CY|
|大鼠 CD68 基因ORF全长cDNA(克隆载体)||RG80307-G|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||RG80307-NF|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), N-His 标签||RG80307-NH|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||RG80307-NM|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体), N-HA 标签||RG80307-NY|
|大鼠 CD68 基因ORF全长cDNA克隆(表达载体)||RG80307-UT|
Macrosialin, also known as CD68 and Gp110, is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.