CD96 cDNA ORF Clone, Rat, C-HA tag

Cat: RG80338-CY
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CD96 cDNA ORF Clone, Rat, C-HA tag 基本信息
基因
种属
Rat
NCBI 参考序列号
参考序列ORF长度
1812 bp
描述
Full length Clone DNA of Rat CD96 molecule with C terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-HA
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD96 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
CD96 molecule
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
  • Anja Fuchs, et al. (2004) Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155). The Journal of Immunology.172 (7): 3994-8.
  • Seth S, et al.(2007) The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochemical and Biophysical Research Communications. 364 (4): 959-65.
  • CD96 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CD96 cDNA ORF Clone in Cloning Vector, Rat RG80338-G
    CD96 cDNA ORF Clone, Rat, untagged RG80338-UT
    CD96 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80338-ACGLN
    CD96 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80338-ACG
    CD96 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80338-ACR
    CD96 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80338-CF
    CD96 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80338-NF
    CD96 cDNA ORF Clone, Rat, C-His tag RG80338-CH
    CD96 cDNA ORF Clone, Rat, N-His tag RG80338-NH
    CD96 cDNA ORF Clone, Rat, N-HA tag RG80338-NY
    CD96 cDNA ORF Clone, Rat, C-Myc tag RG80338-CM
    CD96 cDNA ORF Clone, Rat, N-Myc tag RG80338-NM
    CD96 qPCR Primer Pairs, Rat RP300308

    CD96 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CD96 cDNA ORF Clone in Cloning Vector, Mouse MG50758-G
    CD96 cDNA ORF Clone, Mouse, untagged MG50758-UT
    CD96 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50758-ACGLN
    CD96 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50758-ACG
    CD96 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50758-ACR
    CD96 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50758-CF
    CD96 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50758-NF
    CD96 cDNA ORF Clone, Mouse, C-His tag MG50758-CH
    CD96 cDNA ORF Clone, Mouse, N-His tag MG50758-NH
    CD96 cDNA ORF Clone, Mouse, C-HA tag MG50758-CY
    CD96 cDNA ORF Clone, Mouse, N-HA tag MG50758-NY
    CD96 cDNA ORF Clone, Mouse, C-Myc tag MG50758-CM
    CD96 cDNA ORF Clone, Mouse, N-Myc tag MG50758-NM
    CD96 qPCR Primer Pairs, Mouse MP200732

    CD96 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CD96 cDNA ORF Clone in Cloning Vector, Human HG29657-G
    CD96 cDNA ORF Clone in Cloning Vector, Human HG11202-M
    CD96 cDNA ORF Clone, Human, untagged HG11202-UT
    CD96 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11202-ACGLN
    CD96 cDNA ORF Clone, Human, C-GFPSpark® tag HG11202-ACG
    CD96 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG29657-ACGLN
    CD96 cDNA ORF Clone, Human, C-OFPSpark® tag HG11202-ACR
    CD96 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11202-CF
    CD96 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11202-NF
    CD96 cDNA ORF Clone, Human, C-His tag HG11202-CH
    CD96 cDNA ORF Clone, Human, N-His tag HG11202-NH
    CD96 cDNA ORF Clone, Human, C-HA tag HG11202-CY
    CD96 cDNA ORF Clone, Human, N-HA tag HG11202-NY
    CD96 cDNA ORF Clone, Human, C-Myc tag HG11202-CM
    CD96 cDNA ORF Clone, Human, N-Myc tag HG11202-NM
    CD96 qPCR Primer Pairs, Human HP101107
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