Cathepsin D cDNA ORF Clone, Rat, N-DDK (Flag®) tag

Cat: RG81328-NF
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Cathepsin D cDNA ORF Clone, Rat, N-DDK (Flag®) tag 基本信息
基因
种属
Rat
NCBI 参考序列号
参考序列ORF长度
1224 bp
描述
Full length Clone DNA of Rat cathepsin D with N terminal Flag tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-SP-N-FLAG
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Cathepsin D Background Information

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

Full Name
cathepsin D
References
  • Fusek M, et al. (2005) Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 149(1): 43-50.
  • Minarowska A, et al. (2007) Regulatory role of cathepsin D in apoptosis. Folia Histochem Cytobiol. 45(3): 159-63.
  • Zaidi N, et al. (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun. 376(1): 5-9.
  • Cathepsin D cDNA ORF Clone, Rat, Related Products

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    Cathepsin D cDNA ORF Clone in Cloning Vector, Rat RG81328-U
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    Cathepsin D cDNA ORF Clone, Rat, C-HA tag RG81328-CY
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    Cathepsin D cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    Cathepsin D cDNA ORF Clone in Cloning Vector, Mouse MG50127-M
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    Cathepsin D cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50127-CF
    Cathepsin D cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50127-NF
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    Cathepsin D cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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    Cathepsin D cDNA ORF Clone, Human, C-GFPSpark® tag HG12517-ACG
    Cathepsin D cDNA ORF Clone, Human, C-OFPSpark® tag HG12517-ACR
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    Cathepsin D cDNA ORF Clone, Human, N-DDK (Flag®) tag HG12517-NF
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    Cathepsin D cDNA ORF Clone, Human, N-His tag HG12517-NH
    Cathepsin D cDNA ORF Clone, Human, C-HA tag HG12517-CY
    Cathepsin D cDNA ORF Clone, Human, N-HA tag HG12517-NY
    Cathepsin D cDNA ORF Clone, Human, C-Myc tag HG12517-CM
    Cathepsin D cDNA ORF Clone, Human, N-Myc tag HG12517-NM
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