ESAM cDNA ORF Clone, Rat, untagged

Cat: RG80241-UT
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ESAM cDNA ORF Clone, Rat, untagged 基本信息
基因
种属
Rat
NCBI 参考序列号
参考序列ORF长度
1185 bp
描述
Full length Clone DNA of Rat endothelial cell adhesion molecule.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-untagged
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Ampicillin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ESAM Background Information

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Full Name
endothelial cell adhesion molecule
References
  • Ishida T, et al. (2003) Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem. 278(36): 34598-604.
  • Wegmann F, et al. (2004) Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Exp Cell Res. 300(1): 121-33.
  • Wegmann F, et al. (2006) ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med. 203(7): 1671-7.
  • Hara T, et al. (2009) Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy. Microvasc Res. 77(3): 348-55.
  • Cangara HM, et al. (2010) Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis. Microvasc Res. 80(1): 133-41.
  • ESAM cDNA ORF Clone, Rat, Related Products

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    ESAM cDNA ORF Clone in Cloning Vector, Rat RG80241-G
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    ESAM cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80241-NF
    ESAM cDNA ORF Clone, Rat, C-His tag RG80241-CH
    ESAM cDNA ORF Clone, Rat, N-His tag RG80241-NH
    ESAM cDNA ORF Clone, Rat, C-HA tag RG80241-CY
    ESAM cDNA ORF Clone, Rat, N-HA tag RG80241-NY
    ESAM cDNA ORF Clone, Rat, C-Myc tag RG80241-CM
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    ESAM cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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    ESAM cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10187-NF
    ESAM cDNA ORF Clone, Human, C-His tag HG10187-CH
    ESAM cDNA ORF Clone, Human, N-His tag HG10187-NH
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    ESAM cDNA ORF Clone, Human, N-HA tag HG10187-NY
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