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大鼠 IL22RA1 基因全长ORF克隆 (表达载体), N端HA标签

产品数据评论相关产品实验方法
Rat IL22RA1 cDNA Clone产品信息
NCBI注册码:NM_001191869.1
参考序列ORF长度:1734bp
cDNA基因描述:Full length Clone DNA of Rattus norvegicus interleukin22receptor,alpha1 with N terminal HA tag.
分子别称:RGD1559655, Il22ra1
分子种属:Rat
载体:pCMV3-SP-N-HA
质粒:
限制性酶切位点:
Tag序列:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
序列信息:
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Kanamycin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Product nameProduct name
重组狗 IL22RA1 / IL22R 蛋白 (Fc 标签)重组狗 IL22RA1 / IL22R 蛋白 (His 标签)Rat IL-22R / IL22RA1 Protein (ECD, His Tag)Rat IL-22R / IL22RA1 Protein (ECD, Fc Tag)重组人 IL29 / IFNL1 蛋白重组人 IL20RA / IL-20RA 蛋白 (ECD, Fc 标签)Cynomolgus IL20RB Protein (Fc Tag)Cynomolgus IL20RB Protein (His Tag)重组小鼠 IL-28B / IFN-lambda-3 蛋白 (His 标签)重组狗 IL20RA / IL-20RA 蛋白 (Fc 标签)重组野猪 IL10 / Interleukin-10 蛋白重组人 IL19 / Interleukin-19 蛋白 (His 标签)重组人 IL19 / Interleukin-19 蛋白 (His 标签)重组猫 IL10 / Interleukin-10 蛋白重组人 IL20RA 蛋白 (His 标签)Human IL-28B / IFN-lambda-3 Protein (His Tag)重组人 IL10Rb 蛋白 (His & Fc 标签)重组人 IL10Rb 蛋白 (His 标签)重组人 IL10 / Interleukin-10 蛋白 (His 标签)重组人 IL10 / Interleukin-10 蛋白重组人 IL22BP / IL22RA2 蛋白 (His & Fc 标签)重组人 IL22BP / IL22RA2 蛋白 (His 标签)重组人 IFNL3 / IL28B / Interleukin-28B 蛋白 (His 标签)重组人 IL-24 / MDA-7 蛋白 (His 标签)重组人 IL-29 / Interleukin-29 蛋白 (His 标签)重组人 STAT1 / p91 蛋白 (His & GST 标签)重组人 IL22 / IL-22 / Interleukin 22 蛋白重组人 IL20 / Interleukin-20 蛋白重组人 STAT4 蛋白 (His 标签)重组人 STAT6 蛋白 (His 标签)重组小鼠 IL10RB / IL10R2 蛋白 (Fc 标签)重组小鼠 IL10RB / IL10R2 蛋白 (His 标签)重组大鼠 IL10RB / IL10R2 蛋白 (Fc 标签)重组大鼠 IL20RB 蛋白 (Fc 标签)重组大鼠 IL20RB 蛋白 (His 标签)重组大鼠 IL20 / Interleukin-20 蛋白重组食蟹猴 IL10RA 蛋白 (Fc 标签)重组大鼠 IL10 / Interleukin-10 蛋白
研究背景

IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

参考资料
  • Xie MH, et al. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 275(40):31335-9.
  • Xu W, et al. (2001) A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci. 98(17):9511-6.
  • Wu PW, et al. (2008) IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. J Mol Biol. 382(5):1168-83.
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    货号: RG80453-NY
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