|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||RG80454-ACG|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||RG80454-ACR|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||RG80454-CF|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-His 标签||RG80454-CH|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||RG80454-CM|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), C-HA 标签||RG80454-CY|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA(克隆载体)||RG80454-G|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||RG80454-NF|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), N-His 标签||RG80454-NH|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||RG80454-NM|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体), N-HA 标签||RG80454-NY|
|大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体)||RG80454-UT|
Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.