( We provide with PROM1 qPCR primers for gene expression analysis, RP300295 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||RG80324-ACG|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||RG80324-ACR|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||RG80324-CF|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-His 标签||RG80324-CH|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||RG80324-CM|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), C-HA 标签||RG80324-CY|
|大鼠 PROM1 基因ORF全长cDNA(克隆载体)||RG80324-G|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||RG80324-NF|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), N-His 标签||RG80324-NH|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||RG80324-NM|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体), N-HA 标签||RG80324-NY|
|大鼠 PROM1 基因ORF全长cDNA克隆(表达载体)||RG80324-UT|
CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.