**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.
CD133 cDNA ORF Clone, Rat, Related Products
CD133 cDNA ORF Clone, Mouse, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| CD133 cDNA ORF Clone in Cloning Vector, Mouse | MG57703-U |
| CD133 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag | MG57703-ACGLN |
CD133 cDNA ORF Clone, Human, Related Products
