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大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-His 标签

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Rat PTPRC cDNA Clone产品信息
NCBI注册码:NM_001109890.1
参考序列ORF长度:3426bp
cDNA基因描述:Full length Clone DNA of Rattus norvegicus protein tyrosine phosphatase, receptor type, C, transcript variant 1 with N terminal His tag.
分子别称:Lca, RT7, CD45, L-CA, T200, Ptprc
分子种属:Rat
载体:pCMV3-N-His
质粒:
限制性酶切位点:
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列信息:
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Kanamycin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-His 标签 on other vectors
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签RG80296-ACG2550
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签RG80296-ACR2550
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-GFPSpark 标签RG80296-ANG2550
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-OFPSpark 标签RG80296-ANR2550
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-Flag 标签RG80296-CF2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-His 标签RG80296-CH2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-Myc 标签RG80296-CM2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), C-HA 标签RG80296-CY2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA(克隆载体)RG80296-G1160
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签RG80296-NF2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-His 标签RG80296-NH2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-Myc 标签RG80296-NM2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-HA 标签RG80296-NY2370
大鼠 CD45/PTPRC transcript variant 1 基因ORF全长cDNA克隆(表达载体)RG80296-UT2370
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研究背景

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexs or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

参考资料
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Irie-Sasaki J, et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.
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