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S100A9  ELISA试剂盒

All S100A9 Reagents

S100A9

S100A9 ELISA Kit

S100A9 相关研究领域

S100A9 相关信号通路

    S100A9 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    S100A9 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    S100A9 概述&蛋白信息

    S100A9 研究背景

    基因概述: The protein encoded by S100A9 gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: ATP + (ribonucleotide)(n) + (ribonucleotide)(m) = AMP + diphosphate + (ribonucleotide)(n+m).
    亚单位结构: Homodimer. Preferentially exists as a heterodimer or heterotetramer with S100A8 known as calprotectin (S100A8/A9). S100A9 interacts with ATP2A2 (By similarity). S100A9 interacts with AGER, and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. S100A9 binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions. S100A9 interacts with beta-APP40 (beta-amyloid protein 40) peptide of APP. Calprotectin (S100A8/9) interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin (S100A8/A9) interacts with ANXA6 and associates with tubulin filaments in activated monocytes. Calprotectin (S100A8/9) interacts with NCF2/P67PHOX, RAC1, RAC2, CYBA and CYBB. {ECO:0000250, ECO:0000269|PubMed:11708798, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15642721, ECO:0000269|PubMed:16258195, ECO:0000269|PubMed:17553524, ECO:0000269|PubMed:18786929, ECO:0000269|PubMed:19087201, ECO:0000269|PubMed:19122197, ECO:0000269|PubMed:19402754, ECO:0000269|PubMed:22457725, ECO:0000269|PubMed:22808130, ECO:0000269|PubMed:8423249, ECO:0000269|PubMed:9083090}.
    亚细胞定位: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.
    组织特异性: Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers. {ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:3313057, ECO:0000269|PubMed:3405210, ECO:0000269|PubMed:8423249, ECO:0000269|PubMed:9083090}.
    翻译后修饰: Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization. {ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:2478889}.
    相似的序列: Belongs to the S-100 family. {ECO:0000305}.; Contains 2 EF-hand domains. {ECO:0000255|PROSITE-ProRule:PRU00448}.
    General information above from UniProt

    S100A9 别称

    MIF,NIF,CFAG,L1Ag,60B8AG,CAGB,CGLB,LIAG,MRP14,MAC387,p14, [homo-sapiens]
    CFAG,LIAG,MAC387,MIF,MRP14,P14,60B8AG,CAGB,CGLB,L1AG,MRP-14,NIF,S100A9, [human]
    P14,60B8Ag,BEE22,L1Ag,MRP14,AW546964,Cagb,GAGB,MRP-14,S100a9, [mouse]
    P14,60B8Ag,Cagb,GAGB,L1Ag,BEE22,MRP14,AW546964, [mus-musculus]

    S100A9 相关文献

  • Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23.
  • Fanò G. et al., 1995, Prog Neurobiol. 46 (1): 71-82.
  • Vogl T. et al., 2004, Blood. 104: 4260-8.
  • Viemann D. et al., 2005, Blood. 105: 2955-62.
  • Nakatani Y. et al., 2005, Mediators Inflamm. 2005: 280-92.
  • Bjoerk P. et al., 2009, PLoS Biol. 7: E97-E97.
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