SIRP gamma / SIRPG (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All SIRP gamma / SIRPG reagents are produced in house and quality controlled, including 3 SIRP gamma / SIRPG Antibody, 28 SIRP gamma / SIRPG Gene, 4 SIRP gamma / SIRPG Lysate, 5 SIRP gamma / SIRPG Protein, 1 SIRP gamma / SIRPG qPCR. All SIRP gamma / SIRPG reagents are ready to use.

SIRP gamma / SIRPG Protein (5)

SIRP gamma / SIRPG Antibody (3)

SIRP gamma / SIRPG cDNA Clone (28)

NM_018556.3

克隆载体 cDNA 产品

In lentiviral vector

BC064532

In expression vector

In lentiviral vector

XM_001113667.2

克隆载体 cDNA 产品

In lentiviral vector

SIRP gamma / SIRPG qPCR Primer (1)

SIRP gamma / SIRPG Lysate (4)

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SIRP gamma / SIRPG 分子背景

Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD2+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

SIRP gamma / SIRPG 参考文献

  • Meador JA, et al. (2011) p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res. 175(6): 689-99.
  • Reddy MV, et al. (2011) Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun. 12(3): 208-12.
  • Kawasaki M, et al. (2009) Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. Clin Exp Rheumatol. 27(2): 260-6.