Anti-STAT6 Antibody

Cat: 13190-RP02
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Anti-STAT6 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-STAT6 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human STAT6
Immunogen
Recombinant Human STAT6 protein (Catalog#13190-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant Human STAT6 (rh STAT6; Catalog#13190-H08B; P42226-1; Met1-Trp847). STAT6 specific IgG was purified by Human STAT6 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-STAT6 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-STAT6 Antibody (Rabbit Polyclonal antibody) Images
Human STAT6 Immunohistochemistry(IHC) 3553
Immunochemical staining of human STAT6 in human malignant melanoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-STAT6 Antibody Alternative Names
Anti-D12S1644 Antibody;Anti-IL-4-STAT Antibody;Anti-STAT6B Antibody;Anti-STAT6C Antibody
STAT6 Background Information

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B. 

Full Name
signal transducer and activator of transcription 6, interleukin-4 induced
References
  • Litterst CM, et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.
  • Stutz AM, et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91.
  • Yang J, et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-STAT6 Antibody Mouse Monoclonal FCM,ICC/IF,IF 13190-MM03
    Anti-STAT6 Antibody Mouse Monoclonal ELISA 13190-MM02
    Anti-STAT6 Antibody (FITC) Mouse Monoclonal FCM 13190-MM03-F
    Anti-STAT6 Antibody (PE) Mouse Monoclonal FCM 13190-MM03-P
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