STUB1: STUB1 Protein | STUB1 Antibody

STUB1 Gene family

STUB1 Protein

STUB1 protein function

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:28813410}.

STUB1 protein expression

Tissue specificity

Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.

Induction

Up-regulated by inflammatory signals in regulatory T-cells (Treg).

STUB1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    303.00
  • Mass (Da)
    34.00

STUB1 Antibody

There are 5 STUB1 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, WB, FCM, ICC/IF, IP. There are 2 STUB1 antibody for IHC-P, 3 STUB1 antibody for ELISA, 2 STUB1 antibody for WB, 1 STUB1 antibody for FCM, 1 STUB1 antibody for ICC/IF, 2 STUB1 antibody for IP. Among all these STUB1 antibodies, there are 2 anti-STUB1 rabbit polyclonal antibodies , 1 anti-STUB1 mouse monoclonal antibodies , 2 anti-STUB1 rabbit monoclonal antibodies . All the STUB1 anbodies are produced in house and all are in stock. STUB1 antibody customerized service is available.

STUB1 Gene

STUB1 gene / cDNA is a protein-coding gene which located on 16p13.3. The STUB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, M.oryzae, N.crassa, A.thaliana, rice, and frog.219 organisms have orthologs with human gene STUB1.