快速订购

Syndecan-1 / SDC1 / CD138 抗体, 兔多抗, 抗原亲和纯化

    产品数据评论相关产品实验方法
    小鼠 SDC1 抗体产品信息
    免疫原:Recombinant Mouse Syndecan-1 / SDC1 / CD138 protein (Catalog#50641-M08H)
    克隆号:
    Ig 类型:Rabbit IgG
    浓度:
    内毒素:
    缓冲液:0.2 μm filtered solution in PBS
    抗体制备方法:Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1 / SDC1 / CD138 (rh Syndecan-1 / SDC1 / CD138; Catalog#50641-M08H; NP_035649.1; Met1-Glu252). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Mouse Syndecan-1 / SDC1 / CD138 affinity chromatography.
    Other SDC1 抗体 Products
    Syndecan-1/CD138/SDC1 研究背景

    Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

    小鼠 Syndecan-1/CD138/SDC1 参考资料
  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
  • Product nameProduct name
    Size / Price
    货号: 50641-T16-200
    目录价: 
    单价:      (You Save: )

    Datasheet & Documentation

    产品数据可能随批次变化,最新数据请详见随货说明书。
    请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”