Anti-Syndecan-1 Antibody

Cat: 50641-T16

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Anti-Syndecan-1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Syndecan-1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Syndecan-1
Immunogen
Recombinant Mouse Syndecan-1 / SDC1 / CD138 protein (Catalog#50641-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1 / SDC1 / CD138 (Catalog#50641-M08H; NP_035649.1; Met1-Glu252). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Mouse Syndecan-1 / SDC1 / CD138 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-Syndecan-1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Syndecan-1 Antibody Alternative Names

Anti-AA408134 Antibody;Anti-AA409076 Antibody;Anti-CD138 Antibody;Anti-Sstn Antibody;Anti-syn-1 Antibody;Anti-Synd Antibody;Anti-Synd1 Antibody

Syndecan-1 Background Information

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Full Name
syndecan 1
References
  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA 80344-T16
    Anti-Syndecan-1 Antibody Rabbit Monoclonal ELISA 50641-R004
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA 50641-RP01
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA,IHC-P 50641-RP02
    Anti-Syndecan-1 Antibody Rabbit Polyclonal WB,IP 100620-T36
    Anti-Syndecan-1 Antibody (APC) Rabbit Monoclonal FCM 11429-R017-A
    Anti-Syndecan-1 Antibody Rabbit Polyclonal WB,IHC-P 11429-RP02
    Anti-Syndecan-1 Antibody (FITC) Rabbit Monoclonal FCM 11429-R017-F
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA 11429-RP01
    Anti-Syndecan-1 Antibody Rabbit Monoclonal ELISA 11429-R001
    Anti-Syndecan-1 Antibody (PE) Rabbit Monoclonal FCM 11429-R017-P
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA 11429-T16
    Anti-Syndecan-1 Antibody Rabbit Polyclonal ELISA,IHC-P 11429-T24
    Anti-Syndecan-1 Antibody Rabbit Monoclonal ELISA,FCM 11429-R017
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