Syndecan-1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Syndecan-1 reagents are produced in house and quality controlled, including 16 Syndecan-1 Antibody, 39 Syndecan-1 Gene, 1 Syndecan-1 IP Kit, 4 Syndecan-1 Lysate, 4 Syndecan-1 Protein, 3 Syndecan-1 qPCR. All Syndecan-1 reagents are ready to use.

Syndecan-1 Protein (4)

Syndecan-1 Antibody (16)

Syndecan-1 cDNA Clone (39)

NM_001006946.1

克隆载体 cDNA 产品

In lentiviral vector

NM_011519.2

克隆载体 cDNA 产品

In lentiviral vector

NM_013026.2

克隆载体 cDNA 产品

In lentiviral vector

Syndecan-1 Lysate (4)

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Syndecan-1 分子背景

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

Syndecan-1 参考文献

  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.