TFPI cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG10564-M-F

This product is not available, please contact order@sinobiological.com for relevant product if required.

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All TFPI Reagents

CRO Services


All TFPI Reagents

TFPI cDNA ORF Clone, Human, C-DDK (Flag®) tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
915 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) with Flag tag.

质粒

启动子
Enhanced CMV promoter
载体
pCMV2-FLAG
限制性酶切位点
KpnI + XhoI (5.4kb + 0.97kb)
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

TFPI cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TFPI cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names

EPI cDNA ORF Clone, Human;LACI cDNA ORF Clone, Human;TFI cDNA ORF Clone, Human;TFPI1 cDNA ORF Clone, Human

TFPI Background Information

Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis.

Full Name
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
References
  • Lwaleed BA, et al. (2006) Tissue factor pathway inhibitor: structure, biology and involvement in disease. J Pathol. 208(3): 327-39.
  • Amirkhosravi A, et al. (2007) The role of tissue factor pathway inhibitor in tumor growth and metastasis. Semin Thromb Hemost. 33(7): 643-52.
  • Maroney SA, et al. (2008) Expression of tissue factor pathway inhibitor by endothelial cells and platelets. Transfus Apher Sci. 38(1): 9-14.
  • TFPI cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    TFPI cDNA ORF Clone, Rat, untagged RG83097-UT
    TFPI cDNA ORF Clone, Rat, C-GFPSpark® tag RG83097-ACG
    TFPI Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG83097-ACGLN
    TFPI cDNA ORF Clone, Rat, C-OFPSpark® tag RG83097-ACR
    TFPI cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG83097-CF
    TFPI cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG83097-NF
    TFPI cDNA ORF Clone, Rat, C-His tag RG83097-CH
    TFPI cDNA ORF Clone, Rat, N-His tag RG83097-NH
    TFPI cDNA ORF Clone, Rat, C-HA tag RG83097-CY
    TFPI cDNA ORF Clone, Rat, N-HA tag RG83097-NY
    TFPI cDNA ORF Clone, Rat, C-Myc tag RG83097-CM
    TFPI cDNA ORF Clone, Rat, N-Myc tag RG83097-NM

    TFPI cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    TFPI cDNA ORF Clone in Cloning Vector, Mouse MG50131-M
    TFPI cDNA ORF Clone, Mouse, untagged MG50131-UT
    TFPI Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50131-ACGLN
    TFPI cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50131-ACG
    TFPI cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50131-ACR
    TFPI cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50131-CF
    TFPI cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50131-NF
    TFPI cDNA ORF Clone, Mouse, C-His tag MG50131-CH
    TFPI cDNA ORF Clone, Mouse, N-His tag MG50131-NH
    TFPI cDNA ORF Clone, Mouse, C-HA tag MG50131-CY
    TFPI cDNA ORF Clone, Mouse, N-HA tag MG50131-NY
    TFPI cDNA ORF Clone, Mouse, C-Myc tag MG50131-CM
    TFPI cDNA ORF Clone, Mouse, N-Myc tag MG50131-NM
    TFPI qPCR Primer Pairs, Mouse MP200161

    TFPI cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    TFPI cDNA ORF Clone in Cloning Vector, Human HG10564-M
    TFPI cDNA ORF Clone, Human, untagged HG10564-UT
    TFPI cDNA ORF Clone, Human, C-GFPSpark® tag HG10564-ACG
    TFPI Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10564-ACGLN
    TFPI cDNA ORF Clone, Human, C-OFPSpark® tag HG10564-ACR
    TFPI cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10564-CF
    TFPI cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10564-NF
    TFPI cDNA ORF Clone, Human, C-His tag HG10564-CH
    TFPI cDNA ORF Clone, Human, N-His tag HG10564-NH
    TFPI cDNA ORF Clone, Human, C-HA tag HG10564-CY
    TFPI cDNA ORF Clone, Human, N-HA tag HG10564-NY
    TFPI cDNA ORF Clone, Human, C-Myc tag HG10564-CM
    TFPI cDNA ORF Clone, Human, N-Myc tag HG10564-NM
    TFPI qPCR Primer Pairs, Human HP100855
    info info
    添加购物车成功! 添加购物车失败!