TGF beta 1 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All TGF beta 1 reagents are produced in house and quality controlled, including 12 TGF beta 1 Antibody, 2 TGF beta 1 ELISA, 52 TGF beta 1 Gene, 1 TGF beta 1 IP Kit, 8 TGF beta 1 Lysate, 9 TGF beta 1 Protein, 3 TGF beta 1 qPCR. All TGF beta 1 reagents are ready to use.

TGF beta 1 Protein (9)

TGF beta 1 Antibody (12)

TGF beta 1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

TGF beta 1 cDNA Clone (52)

NM_000660.4

克隆载体 cDNA 产品

In lentiviral vector

NM_011577.1

克隆载体 cDNA 产品

In lentiviral vector

NM_021578.2

克隆载体 cDNA 产品

In lentiviral vector

NM_001003309.1

克隆载体 cDNA 产品

In lentiviral vector

TGF beta 1 Lysate (8)

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TGF beta 1 分子背景

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

TGF beta 1 参考文献

  • Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
  • Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
  • Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
  • Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.