TGF beta 1: TGF beta 1 Protein | TGF beta 1 Antibody

TGF beta 1 Gene family

TGF beta 1 Background

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

Reference for TGF beta 1

  • Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
  • Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
  • Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
  • Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.

TGF beta 1 Protein

TGF beta 1 protein function

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292). {ECO:0000250|UniProtKB:P04202, ECO:0000269|PubMed:25310401, ECO:0000269|PubMed:25893292}.

TGF beta 1 protein expression

Tissue specificity

Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

Induction

Activated in vitro at pH below 3.5 and over 12.5.

TGF beta 1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    390.00
  • Mass (Da)
    44.00

TGF beta 1 Antibody

There are 14 TGF beta 1 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), WB, IP. There are 12 TGF beta 1 antibody for ELISA, 1 TGF beta 1 antibody for ELISA(Cap), 3 TGF beta 1 antibody for WB, 1 TGF beta 1 antibody for IP. Among all these TGF beta 1 antibodies, there are 4 anti-TGF beta 1 mouse monoclonal antibodies , 2 anti-TGF beta 1 rabbit monoclonal antibodies , 8 anti-TGF beta 1 rabbit polyclonal antibodies . All the TGF beta 1 anbodies are produced in house and all are in stock. TGF beta 1 antibody customerized service is available.

TGF beta 1 Gene

TGFB1 gene / cDNA is a protein-coding gene which located on 19q13.1. The TGFB1 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, and frog.129 organisms have orthologs with human gene TGFB1.