TREM-2 cDNA ORF Clone, Human, untagged

Cat: HG11084-M-N

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TREM-2 cDNA ORF Clone, Human, untagged 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
693 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutation 6G/A not causing the amino acid variation.
描述
ORF Clone of Human triggering receptor expressed on myeloid cells 2 DNA.

质粒

载体
pCMV/hygro
限制性酶切位点
KpnI + XhoI
质控
The plasmid is confirmed by full-length sequencing.

筛选

应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

TREM-2 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TREM-2 cDNA ORF Clone, Human, untagged Validated Images

other Green fluorescent protein / GFP Gene Plasmid Map 7139

TREM-2 cDNA ORF Clone, Human, untagged Alternative Names

TREM-2 cDNA ORF Clone, Human;Trem2a cDNA ORF Clone, Human;Trem2b cDNA ORF Clone, Human;Trem2c cDNA ORF Clone, Human

TREM-2 Background Information

Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

Full Name
triggering receptor expressed on myeloid cells 2
References
  • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
  • Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. 
  • Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48.
  • Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
  • Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.
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