Anti-UCHL3 Antibody

Cat: 80087-R028
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Anti-UCHL3 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-UCHL3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat UCHL3
No cross-reactivity in ELISA with Human UCHL3 Mouse UCHL3
Immunogen
Recombinant Rat UCHL3 protein (Catalog#80087-R07E)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat UCHL3 (rR UCHL3; Catalog#80087-R07E; Q91Y78; Glu2-Ala230).
Source
Monoclonal Rabbit IgG Clone #028
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-UCHL3 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

UCHL3 Background Information

Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase which belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.

Full Name
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
References
  • Wood,M.A. et al., 2005, Hippocampus  15 (5):610-21.
  • Kwon,J. et al., 2006, Exp Anim  55 (1):35-43.
  • Setsuie,R. et al., 2009, Neurochem Int  54 (5-6):314-21.
  • Setsuie,R. et al., 2010, Neurochem Int  56 (8):911-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-UCHL3 Antibody Rabbit Monoclonal WB,ELISA,IHC-P,IP 80087-R007
    Anti-UCHL3 Antibody Rabbit Polyclonal WB,ELISA,IP 80087-RP02
    Anti-UCHL3 Antibody Rabbit Monoclonal ELISA 50692-R033
    Anti-UCHL3 Antibody Rabbit Monoclonal WB,IP 50692-R153
    Anti-UCHL3 Antibody Rabbit Polyclonal ELISA 50692-RP01
    Anti-UCHL3 Antibody Rabbit Monoclonal IHC-P 50692-R204
    Anti-UCHL3 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 50692-RP02
    Anti-UCHL3 Antibody Rabbit Polyclonal ELISA 11634-RP01
    Anti-UCHL3 Antibody Rabbit Polyclonal WB,ELISA,IP 11634-RP02
    Anti-UCHL3 Antibody Rabbit Monoclonal ELISA 11634-R001
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