VEGFA: VEGFA Protein | VEGFA Antibody

VEGFA Gene family

VEGFA Background

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

Reference for VEGFA

  • Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
  • Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
  • Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
  • Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
  • Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
  • Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.

VEGFA Protein

VEGFA protein function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q00731, ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009}.

VEGFA protein expression

Tissue specificity

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

Induction

By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations.

VEGFA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    232.00
  • Mass (Da)
    27.00

VEGFA Antibody

There are 23 VEGFA antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap), WB, IHC-P, ICC/IF, Neutralization. There are 15 VEGFA antibody for ELISA, 2 VEGFA antibody for ELISA(Det), 2 VEGFA antibody for ELISA(Cap), 2 VEGFA antibody for WB, 5 VEGFA antibody for IHC-P, 2 VEGFA antibody for ICC/IF, 2 VEGFA antibody for Neutralization. Among all these VEGFA antibodies, there are 7 anti-VEGFA rabbit monoclonal antibodies , 12 anti-VEGFA rabbit polyclonal antibodies , 4 anti-VEGFA mouse monoclonal antibodies . All the VEGFA anbodies are produced in house and all are in stock. VEGFA antibody customerized service is available.

VEGFA Gene

VEGFA gene / cDNA is a protein-coding gene which located on 6p21.1. The VEGFA gene is conserved in dog, cow, mouse, rat, chicken, and zebrafish.230 organisms have orthologs with human gene VEGFA.