Anti-VEGFR2 / KDR Antibody

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Anti-VEGFR2 / KDR Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-VEGFR2 / KDR Antibody
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human VEGFR2 / KDR
免疫原
Recombinant Human VEGFR2 / Flk-1 / CD309 / KDR protein (Catalog#10012-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human VEGFR2 / Flk-1 / CD309 / KDR (rh VEGFR2 / Flk-1 / CD309 / KDR; Catalog#10012-H08H; NP_002244.1; Met1-Glu764). VEGFR2 / Flk-1 / CD309 / KDR specific IgG was purified by Human VEGFR2 / Flk-1 / CD309 / KDR affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-VEGFR2 / KDR Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-VEGFR2 / KDR Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of human VEGFR2 in human liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human VEGFR2 in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-VEGFR2 / KDR Antibody: 别称

Anti-CD309 Antibody; Anti-Flk-1 Antibody; Anti-FLK1 Antibody; Anti-VEGFR Antibody; Anti-VEGFR2 Antibody

VEGFR2 / KDR 背景信息

VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.
全称
kinase insert domain receptor
研究领域
参考文献
  • Shibuya M. (2006) Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium. 13(2): 63-9.
  • Marwick JA, et al. (2010) Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 7(1): 11.
  • Bruns AF, et al. (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic. 11(1): 161-74.
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