Anti-XPNPEP2 Antibody

Cat: 11903-R020
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Anti-XPNPEP2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-XPNPEP2 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human XPNPEP2
Immunogen
Recombinant Human XPNPEP2 protein (Catalog#11903-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human XPNPEP2 (rh XPNPEP2; Catalog#11903-H08H; O43895; Met1-Ala650).
Source
Monoclonal Rabbit IgG Clone #020
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-XPNPEP2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:50-1:200  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-XPNPEP2 Antibody (Rabbit Monoclonal antibody) Images
Human XPNPEP2 Immunohistochemistry(IHC) 3416
Immunochemical staining of human XPNPEP2 in human kidney with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).
Anti-XPNPEP2 Antibody Alternative Names
Anti-AEACEI Antibody;Anti-APP2 Antibody
XPNPEP2 Background Information

Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).

Full Name
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
References
  • Sprinkle TJ, et al. (2000) Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. Arch Biochem Biophys. 378(1): 51-6.
  • Prueitt RL, et al. (2000) Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Cytogenet Cell Genet. 89(1-2): 44-50.
  • Duan QL, et al. (2005) A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 77(4): 617-26.
  • Woodard-Grice AV, et al. (2010) Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 20(9): 532-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-XPNPEP2 Antibody Rabbit Monoclonal ELISA(Det) 11903-R018
    Anti-XPNPEP2 Antibody Rabbit Monoclonal ELISA(Cap) 11903-R108
    Anti-XPNPEP2 Antibody Rabbit Polyclonal ELISA 11903-RP01
    Anti-XPNPEP2 Antibody Rabbit Monoclonal ELISA 11903-R014
    Anti-XPNPEP2 Antibody Rabbit Polyclonal ELISA,IHC-P 11903-RP02
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