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YES1/c-Yes  蛋白,抗体,试剂盒,cDNA克隆

YES1/c-Yes 相关研究领域

YES1/c-Yes 相关信号通路

    YES1/c-Yes 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    YES1/c-Yes 概述&蛋白信息

    YES1/c-Yes 研究背景

    基因概述: YES1 gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. YES1 gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
    亚单位结构: Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. {ECO:0000250, ECO:0000269|PubMed:19807924}.
    亚细胞定位: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
    组织特异性: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}.
    翻译后修饰: Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:9281320, ECO:0000269|PubMed:9794236}.; Palmitoylation at Cys-3 promotes membrane localization. {ECO:0000250}.
    相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SH2 domain. {ECO:0000255|PROSITE-ProRule:PRU00191}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.
    General information above from UniProt

    Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein which belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.

    YES1/c-Yes 别称

    Yes,c-yes,HsT441,P61-YES, [homo-sapiens]
    c-Yes,HsT441,P61-YES,Yes,YES1, [human]
    Yes,AI323763,c-Yes,Yes1, [mouse]
    Yes,p61-Yes, [mus-musculus]

    YES1/c-Yes 相关文献

  • Summy,J.M. et al., 2003, Front Biosci  8 :s185-205.
  • Clump,D.A. et al., 2005, Growth Factors  23 (4):263-72.
  • Nonomura,T. et al., 2007,Int J Oncol  30 (1):105-11.
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