Anti-ALDH1A1 Antibody (FITC)

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Anti-ALDH1A1 Antibody (FITC) (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-ALDH1A1 Antibody (FITC)
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human ALDH1A1
免疫原
Recombinant Human ALDH1A1 / ALDH1 protein (Catalog#11388-H07E)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALDH1A1 / ALDH1 (rh ALDH1A1 / ALDH1; Catalog#11388-H07E; NP_000680.2; Ser2-Ser501) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
来源
Monoclonal Mouse IgG1 Clone #03
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
FITC
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-ALDH1A1 Antibody (FITC) (Mouse Monoclonal 抗体) 图片

Profile of anti-Human ALDH1A1 reactivity on A549 cells analyzed by flow cytometry.

Anti-ALDH1A1 Antibody (FITC): 别称

Anti-ALDC Antibody; Anti-ALDH-E1 Antibody; Anti-ALDH1 Antibody; Anti-ALDH11 Antibody; Anti-HEL-9 Antibody; Anti-HEL-S-53e Antibody; Anti-HEL12 Antibody; Anti-PUMB1 Antibody; Anti-RALDH1 Antibody

ALDH1A1 背景信息

Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 also belongs to the group of corneal crystallins that help maintain the transparency of the cornea. Increased ALDH1A1 activity has been found in the stem cell populations of leukemia and some solid tumors. In tumor specimens, increased ALDH1A1 immunopositivity was found not only in secretory type cancer epithelial cells but also in neuroendocrine tumor populations. ALDH1 has been identified as a reliable marker of breast cancer stem cells. ALDH1 expression in primary cancer is an independent prognostic factor in node-positive breast cancer patients. ALDH1A1 plays a key role in normal hematopoiesis, and as a TLX1 transcriptional target, ALDH1A1 may contribute to the ability of this homeoprotein to alter cell fate and induce tumor growth.
全称
aldehyde dehydrogenase 1 family, member A1
参考文献
  • Li T, et al. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 90(2): 234-44.
  • Levi BP, et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 113(8): 1670-80.
  • Rahman FB, et al. (2006) Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. Zoolog Sci. 23(3): 239-44.
  • Jester JV, et al. (1999). The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci. 112 ( Pt 5): 613-22.
  • Spontaneous formation of tumor spheroid on a hydrophilic filter paper for cancer stem cell enrichment
    Author
    Fu, JJ;Zhou, Y;Shi, XX;Kang, YJ;Lu, ZS;Li, Y;Li, CM;Yu, L;
    Year
    2018
    Journal
    Colloids Surf B Biointerfaces
    Application
    FCM
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