GLA / alpha-Galactosidase A: GLA / alpha-Galactosidase A Protein | GLA / alpha-Galactosidase A Antibody

GLA / alpha-Galactosidase A Background

Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease. Defects in GLA are the cause of Fabry disease (FD) which is a rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Deficiency of GLA leads to the accumulation of glycosphingolipids in the vasculature leading to multiorgan pathology. In addition to well-described microvascular disease, deficiency of GLA is also characterized by premature macrovascular events such as stroke and possibly myocardial infarction.

Reference for GLA / alpha-Galactosidase A

  • Koide T.et al., 1990, FEBS Lett. 259:353-356.
  • Yang C.-C. et al., 2003, Clin. Genet. 63:205-209.
  • Verovnik F. et al.,2004, Eur. J. Hum. Genet. 12:678-681.
  • Nance C.S. et al., 2006, Arch. Neurol. 63:453-457.

GLA / alpha-Galactosidase A Protein

GLA / alpha-Galactosidase A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    429.00
  • Mass (Da)
    48.00

GLA / alpha-Galactosidase A Antibody

There are 10 GLA / alpha-Galactosidase A antibodies which are validated in multiple tissues with various applications, including ELISA(Det), ELISA, WB, ELISA(Cap), IP. There are 1 GLA / alpha-Galactosidase A antibody for ELISA(Det), 8 GLA / alpha-Galactosidase A antibody for ELISA, 4 GLA / alpha-Galactosidase A antibody for WB, 1 GLA / alpha-Galactosidase A antibody for ELISA(Cap), 2 GLA / alpha-Galactosidase A antibody for IP. Among all these GLA / alpha-Galactosidase A antibodies, there are 3 anti-GLA / alpha-Galactosidase A mouse monoclonal antibodies , 2 anti-GLA / alpha-Galactosidase A rabbit monoclonal antibodies , 5 anti-GLA / alpha-Galactosidase A rabbit polyclonal antibodies . All the GLA / alpha-Galactosidase A anbodies are produced in house and all are in stock. GLA / alpha-Galactosidase A antibody customerized service is available.

GLA / alpha-Galactosidase A Gene

GLA gene / cDNA is a protein-coding gene which located on Xq22.1. The GLA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, M.oryzae, A.thaliana, rice, and frog.239 organisms have orthologs with human gene GLA.