Anti-Asialoglycoprotein Receptor 1 Antibody

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Anti-Asialoglycoprotein Receptor 1 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-Asialoglycoprotein Receptor 1 Antibody
经验证的应用
WB,ELISA(Det)
交叉反应
Reacts with: Human
特异性
Human Asialoglycoprotein Receptor 1
免疫原
Recombinant Human ASGPR1 Protein (Catalog#10773-H07H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human ASGPR1 (rh ASGPR1 ; Catalog#10773-H07H; P07306; Gln62-Leu291).
来源
Monoclonal Rabbit IgG Clone #024
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Asialoglycoprotein Receptor 1 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
WB 1:20000-1:100000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human ASGPR1 in ELISA pair set (Catalog: # SEK10773). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10773-R021).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Asialoglycoprotein Receptor 1 Antibody (Rabbit Monoclonal 抗体) 图片

Anti-ASGR1 rabbit monoclonal antibody at 1:20000 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:33 kDa

Observed band size:43 kDa

Anti-Asialoglycoprotein Receptor 1 Antibody: 别称

Anti-ASGPR Antibody; Anti-ASGPR1 Antibody; Anti-CLEC4H1 Antibody; Anti-HL-1 Antibody

Asialoglycoprotein Receptor 1 背景信息

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
全称
asialoglycoprotein receptor 1
参考文献
  • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
  • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.
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