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Anti-CD8 alpha Antibody (PerCP)

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Anti-CD8 alpha Antibody (PerCP) (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-CD8 alpha Antibody (PerCP)
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human CD8 alpha
免疫原
Recombinant Human CD8 alpha/CD8A Protein (Catalog#10980-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD8 alpha/CD8A (rh CD8 alpha/CD8A; Catalog#10980-H08H; NP_001759.3; Met1-Asp182) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
来源
Monoclonal Mouse IgG2b Clone #48
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
偶联物
PerCP
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-CD8 alpha Antibody (PerCP) (Mouse Monoclonal 抗体) 图片

Flow cytometric analysis of Human CD8 alpha expression on human whole blood lymphocytes. Cells were stained with PerCP-conjugated anti-Human CD8 alpha. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Anti-CD8 alpha Antibody (PerCP): 别称

Anti-CD8 Antibody; Anti-CD8 alpha Antibody; Anti-Leu-2 Antibody; Anti-Leu2 Antibody; Anti-MAL Antibody; Anti-p32 Antibody; Anti-p32 186910 Antibody

CD8 alpha 背景信息

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
全称
CD8a molecule
参考文献
    References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
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