Anti-ASGR2 Antibody

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Anti-ASGR2 Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-ASGR2 Antibody
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human ASGR2
免疫原
Recombinant Human ASGR2 / ASGPR2 protein (Catalog#13908-H07H)
制备方法
Produced in rabbits immunized with purified, recombinant Human ASGR2 / ASGPR2 (rh ASGR2 / ASGPR2; Catalog#13908-H07H; P07307-1; Gln80-Ala311). ASGR2 / ASGPR2 specific IgG was purified by Human ASGR2 / ASGPR2 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ASGR2 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ASGR2 Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining of human ASGR2 in human liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-ASGR2 Antibody: 别称

Anti-ASGP-R2 Antibody; Anti-ASGPR2 Antibody; Anti-CLEC4H2 Antibody; Anti-HBXBP Antibody; Anti-HL-2 Antibody

ASGR2 背景信息

ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.
全称
asialoglycoprotein receptor 2
参考文献
  • Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.
  • Zhang X, et al. (2011) Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro. Arch Virol. 156(4):637-45.
  • Guy CS, et al. (2011) Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor. Hepatology. 54(3):1043-50.
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