Mesothelin (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Mesothelin reagents are produced in house and quality controlled, including 2 Mesothelin Antibody, 16 Mesothelin Gene, 4 Mesothelin Lysate, 6 Mesothelin Protein, 1 Mesothelin qPCR. All Mesothelin reagents are ready to use.

Mesothelin Protein (6)

    Mesothelin Antibody (2)

      Mesothelin cDNA Clone (16)

      BC009272

      克隆载体 cDNA 产品

      In lentiviral vector

      In expression vector

      In lentiviral vector

      Mesothelin qPCR Primer (1)

      Mesothelin Lysate (4)

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        Mesothelin 分子背景

        Megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised by several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.

        Mesothelin 参考文献

        • Chang MC, et al. (2012) Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J. 442 (2): 293-302.
        • Nelson HH, et al. (2011) The relationship between tumor MSLN methylation and serum mesothelin (SMRP) in mesothelioma. Epigenetics. 6 (8): 1029-34.
        • Bournet B, et al. (2012) Gene expression signature of advanced pancreatic ductal adenocarcinoma using low density array on endoscopic ultrasound-guided fine needle aspiration samples. Pancreatology. 12 (1): 27-34.

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