TBG (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All TBG reagents are produced in house and quality controlled, including 7 TBG Antibody, 26 TBG Gene, 2 TBG Lysate, 2 TBG Protein, 2 TBG qPCR. All TBG reagents are ready to use.

TBG Protein (2)

    TBG Antibody (7)

      TBG cDNA Clone (26)

      NM_000354.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_177920.4

      克隆载体 cDNA 产品

      In lentiviral vector

      TBG Lysate (2)

        TBG 分子背景

        Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to theserpin family. TBG is synthesized primarily in theliveras a 54 kDa protein.TBG is genomically aserpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins(along with transthyretin and albumin) responsible for carrying thethyroidhormones thyroxine(T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 inserum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with itsligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

        TBG 参考文献

        • Flink I.L., et al.,(1986), Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc. Natl. Acad. Sci. U.S.A. 83:7708-7712.
        • Akbari M.T., et al., (1993), The structure of the human thyroxine binding globulin (TBG) gene.Biochim. Biophys. Acta 1216:446-454.
        • Hayashi Y., et al.,(1993), Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.Mol. Endocrinol. 7:1049-1060.

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