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CD antigens / Cluster of differentiation

CD antigens chart

CD 1-50   CD 51-100   CD 101-150   CD 151-200   CD 201-250   CD 251-300   CD 301-
CD 1-50                        
Name Alias Function
CD1b T6 Antigen presenting protein
CD1c R7, CD1, CD1A, BDCA1 Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1d R3G1 Antigen presenting protein
CD2 T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R Adhesion between T-cells and other cell types and T-cell activation.
CD3d T3D, IMD19, CD3-DELTA T-cell activation signaling and regulation of TCR expression
CD3e T3E, TCRE,CD3 epsilon T-cell activation signaling and regulation of TCR expression
CD3G T3G, IMD17, CD3-GAMMA T-cell activation signaling and regulation of TCR expression
CD4 T4 T-cell activation, thymic differentiation and receptor for HIV
CD5 T1, Tp67, LEU1 Regulates T-cell receptor signaling
CD6 T12, OX52, TP120 T-cell activation and cell adhesion
CD7 LEU 9, GP40, TP41 T-cell interactions
CD8a T8, Leu-2, MAL,CD8 alpha Co-receptor for MHC class 1 molecules
CD8b CD8B1,P37 Co-receptor for MHC class 1 molecules
CD9 p24, MRP-1, 5H9 antigen, MIC3, TSPAN29, GIG2 Platelet activation and aggregation, and cell adhesion and cell motility
CD10 CALLA, NEP, gp100, Neprilysin, SFE, MME, EPN Peptidase, regulates B-cell growth
CD11a LFA-1, LFA1A, ITGAL Intracellular adhesion and costimulation.
CD11c p150, 95, CR4, integrin αX, LFA-1A, ITGAX Cell adhesion
CD13 Aminopeptidase N, APN, ANPEP,PEPN Aminopeptidase
CD14 LPS-R Receptor for complex of LPS and LBP
CD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias
CD16a FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3 Low affinity Fc receptor. Mediates phagocytosis and antibody-dependent T-cell-mediated cytotoxicity
CD16b FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 Low affinity Fc receptor
CD18 Integrin β2, ITGB2, MFI7 Adhesion, cell signaling
CD19 B4, Leu-12 Regulates B-cell development, activation and differentiation. Signal transduction
CD20 B1, Bp35, MS4A1 B-cell activation and proliferation
CD21 C3DR, CR2, EBV-R Signal transduction. Regulator of complement activation
CD22 BL-CAM, Siglec-2, Leu-14 B-cell adhesion and signal transduction
CD23 FcεRII, BLAST-2, FCER2, CLEC4J Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. Key molecule for B-cell activation and growth
CD24 BA-1, Nectadrin Regulation of B-cell proliferation and differentiation
CD25 Tac, p55, IL2RA Receptor for IL2
CD26 DPP IV, DPP4, ADABP, ADCP2 Exoprotease. HIV pathogenesis
CD27 T14, TNFRSF 7, CD27L receptor Costimulation of B- and T-cell activation
CD28 TP44, T44 T-cell proliferation, survival, IL-2 production, and Th2 cell development
CD39 Integrin β1, ITGB1, FNRB Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration
CD30 Ki-1, TNFRSF8 Regulates lymphocyte proliferation and cell death. Activation of NF-κB
CD31 PECAM-1 Cell adhesion. Plays a key role in leukocyte trafficking across endothelium
CD32 FCG2, FCGR2A1, FCGR2 Regulation of B-cell function. Induces phagocytosis and mediator release.
CD32a FcγRII, FCGR2A,Fc gamma RIIA Innate and adaptive immune responses
CD32b FcγRII, FCGR2B,Fc gamma RIIB Phagocytosis of immune complexes and regulation of antibody production
CD33 p67, Siglec-3 Cell adhesion, cell-cell signaling, inhibitory receptor, and apoptosis
CD34 0 Cell adhesion
CD35 CR1, C3b/C4b receptor Receptor for complement components C3b and C4b. Mediates adhesion and phagocytosis
CD36 GPIV, GP3B, GP4, SCARB3 Cell adhesion, cholesterol transport, scavenger receptor
CD37 TSPAN26,GP52-40 Signal transduction. Regulates T-cell proliferation
CD38 T10, ADPRC1,ADP ribosyl cyclase 1 Cell adhesion and signal transduction
CD39 NTPDase 1, ENTPD1 B-cell adhesion. Protects activated cells from lysis
CD40 TNFRSF5 Cell adhesion, cell proliferation, and signal transduction
CD41 ITGA2B Platelet activation and aggregation.
CD42c GPIbb,GPIBB Platelet adhesion and aggregation
CD43 Leukosialin, sialophorin, SPN Cell adhesion and T cell activation
CD44 H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III Cell adhesion and migration
CD45 LCA, T200, B220, PTPRC Critical for B- and T-cell receptor mediated activation. Regullar of cell growth and differentiation
CD46 MCP, TLX Inhibitory complement activation
CD47 IAP, MER6 Cell adhesion and signal transduction
CD48 Blast-1, BCM1 Cell adhesion and T-cell costimulation
CD49b VLA-2, ITGA2 Adhesion and platelet aggregation.
CD49c VLA-3, ITGA3 Adhesion and signal transduction
CD49e VLA-5, ITGA5 Adhesion, regulation of cell survival and apoptosis
CD49f VLA-6, ITGA6 Embryogenesis, adhesion and cell migration
CD50 ICAM-3 Adhesion and costimulation
CD 51-100
Name Alias Function
CD51 Vitronectin receptor, ITGAV, MSK8 Adhesion and signal transduction
CD52 CAMPATH-1, HE5, CDW52 Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity
CD53 Tetraspanin-25, MOX44 Signal transduction. Cell adhesion, activation, and migration
CD54 ICAM-1 Cell adhesion, lymphocyte activation, and migration
CD55 DAF Regulates complement activation. Signal transduction
CD56 NCAM1 Homophilic and heterophilic adhesion
CD57 B3GAT1, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1 Adhesion molecule.
CD58 LFA-3 APC-T-cell adhesion. Killer target cell interaction.
CD59 Protectin, MAC- inhibitor Prevents complement polymerization. Protects cells from complement mediated lysis
CD61 GPIIIa, ITGB3, GP3A Cell adhesion
CD62E E-selectin, ELAM-1, SELE Tumor cell adhesion and angiogenesis
CD62L L-selectin, LECAM-1, SELL Leukocyte rolling and homing on activated endothelium
CD62P P-selectin, PADGEM, SELP, LECAM3 Cell adhesion
CD63 LIMP, LAMP-3, MLA1 Cell growth and motility regulation; complexes with integrins
CD64 FcγRI, FCGR1, FCGR1A Innate and adaptive immune responses
CD66a BGP-1, NCA-160, CEACAM1 Neutrophil activation, homophilic and heterophilic adhesion
CD66b CD67, CGM6, CEACAM8 Cell adhesion and neutrophil activation
Cell adhesion and neutrophil activation
CD66d CGM1, CEACAM3 Cell adhesion and neutrophil activation
CD66e CEA, CEACAM5 Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD66f PSG1, Sp-1, PSBG1 Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways
CD68 Macrosialin, gp110, KP1 Macrophage homing
CD69 AIM, CLEC2C, EA1 Signal transmission in NK cells and platelets
CD70 Ki-24, CD27L, TNFSF7 Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation.
CD71 T9, TFRC Controls iron uptake during cell proliferation
CD72 Lyb-2, Ly-19, Ly-32 B-cell activation and proliferation
CD73 5’-nucleotidase, NT5E Nucleotidase
CD74 LN2, Ii, DHLAG MHC class II antigen processing
CD75 ST6GAL1, Sialyltransferase 1 Functional maturation of B lymphocytes
CD77 Gb3, Pk blood group, BLA, A4GALT Induces apoptosis
CD79a MB1, IGA, Ig-alpha Subunit of B-cell antigen receptor.Signal transduction
CD79b B29, IGB, Ig-beta Subunit of B-cell antigen receptor.Signal transduction
CD80 B7, B7-1, BB1 Costimulation of T-cell activation and proliferation.
CD81 TAPA-1, Tetraspanin-28 Signal transduction and Cell adhesion
CD82 R2, KAI1, Tetraspanin-27 Signal transduction
CD83 HB15 Antigen presentation and immune stimulation
CD84 SLAM5 Homophilic adhesion molecule. Enhances T-cell activation and cytokine production
CD85a LILRB3, ILT5, LIR3 Immune regulation
CD85c LILRB5, LIR8 Immune regulation
CD85d LILRB2, ILT4, LIR2, MIR10 Down regulates the immune response and involved in the development of tolerance
CD85e LILRA3, ILT6, LIR4 May be involved in triggering innate immune responses
CD85f LILRA5, ILT11, LIR9 May be involved in triggering innate immune responses
CD85i LILRA1, LIR6 May be involved in triggering innate immune responses
CD85j LILRB1, ILT2, LIR1 Inhibits cytotoxicity in NK and T cells upon ligand binding
CD86 B70, B7-2, CD28LG2 Costimulation of T-cell activation and proliferation
CD87 UPA-R, PLAUR, MO3 Cell chemotaxis and adhesion
CD89 FcαR, FCAR IgA Fc receptor
CD90 Thy-1 Costimulation of lymphocytes and cell adhesion
CD91 LRP1,A2MR,APOER Endocytic receptor involved in intracellular signaling, lipid homeostasis, and phagocytosis of apoptotic cells
CD93 C1qR, C1QR1, MXRA4 Cell adhesion and clearance of apoptotic cells
CD95 Apo-1, FASLG, APTL, TNFRSF6 Induces apoptosis
CD96 TACTILE Involved in adhesive interactions of activated T cells and NK cells
CD97 ADGRE5 Neutrophil migration, cell adhesion and signaling
CD98 4F2hc, SLC3A2, MDU1 Cell activation and cell aggregation
CD99 MIC2, E2 Leukocyte migration, T-cell activation and cell adhesion
CD100 Semaphorin 4D, SEMA4D Enhancement of B-cell and dendritic cell responses
CD 101-150
Name Alias Function
CD102 ICAM-2 Adhesion, costimulation and lymphocyte recirculation
CD103 HUMINAE, ITGA1 Lymphocyte retention. Receptor for E-cadherin.
CD105 Endoglin, ENG, END Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD106 VCAM-1, L1CAM Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD107a LAMP-1 Cell adhesion
CD107b LAMP-2 May be involved in leukocyte adhesion.Implicated in tumor cell metastasis
CD108 Semaphorin 7A, SEMA7A Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development
CD111 PVRL1, PRR1, Nectin-1, HVEC Entry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms
CD112 PVRL2, PRR2, Nectin-2, HVEB Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus
CD113 PVRL3, Nectin-3 Adhesion molecule that interacts with afadin
CD114 GCSFR, CSF3R Myeloid cell proliferation and differentiation
CD115 M-CSFR, c-fms, CSF1R Monocytic cell proliferation and differentiation
CD116 GM-CSFRα, CSF2RA, GM-CSFR Myeloid cell hematopoiesis and differentiation
CD117 c-kit, SCFR, KIT Crucial for development of gonadal and pigment stem cells
CD118 LIFR, gp190 Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD119 IFNγR, IFNGR1 Receptor for interferon gamma, a multifunctional immunomodulator
CD120a TNFR-I, TNFRSF1A, TNFR1 Receptor for TNF
CD120b TNFR-II, TNFRSF1B, TNFR2 Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis
CD121a IL-1R type I, IL1R1, IL1R1, IL-1 RI Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD121b IL-1R, type II, IL1R2, IL-1R2
Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD122 IL-2Rβ, IL-2RB Receptor for IL2 and IL15
CD123 IL-3R, IL3RA Receptor for IL3
CD124 IL4RA, IL4R Receptor for IL4 and IL13
CD125 IL5RA, IL5R Receptor for IL5
CD126 IL-6R, IL6R, gp80 Receptor for IL6
CD127 IL-7R, IL7R Receptor for IL7
CD130 IL-6Rβ, gp130, IL6ST Transmits activities of IL6, IL11, LIF and CNF
CD131 IL-3R common β, IL3RB, CSF2RB, IL5RB Component of the high affinity IL3, GM-CSF and IL5 receptors
CD132 IL2RG, Common γ Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15.
CD134 OX-40, TNFRSF4 T-cell activation, proliferation and differentiation, apoptosis and cell adhesion
CD135 Flt3, Flk2 Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD136 MSP-R, RON, PTK8, MST1R Receptor for MSP which regulates cell adhesion, motility, growth, and survival.
CD137 TNFRSF9, 4-1BB, CDw137, ILA Costimulation of T-cell activation. Regulates T-cell-dependent immune responses.
CD137L 4-1BB, TNFRSF9, ILA Costimulation of T-cell activation
CD138 Syndecan-1, SDC Cell proliferation, cell migration, and cell-matrix interactions
CD140a PDGFRα, PDGFRA Cell proliferation, differentiation and survival
CD140b PDGFRβ, PDGFRB Cell proliferation, differentiation and survival
CD141 THBD, AHUS6, BDCA3, THPH12, THRM, TM Activation of protein C and initiation of protein C anti-coagulant pathway.
CD142 Tissue Factor, F3 Initiates blood clotting
CD143 ACE1, DCP, DCP1, ICH, MVCD3 Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin. Cell adhesion.
CD144 VE-Cadherin, Cadherin-5 Cell adhesion.
CD146 MUC18, S-endo, MCAM Cell adhesion. Involved in heterophilic cell to cell interactions
CD147 Neurothelin, basoglin, Basigin, BSG,EMMPRIN Cell adhesion and T-cell activation
CD148 HPTP-eta, DEP1, PTPRJ Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation
CD150 SLAM, SLAMF1, IPO-3 Costimulation of T-cells and B-cells
CD 151-200
Name Alias Function
CD151 PETA-3, GP27, SFA-1, Cell adhesion.
CD152 CTLA-4 T-cell inhibition
CD153 CD30L, TNFSF8 Binds to CD30 and induces proliferation of T-cells
CD154 CD40L, CD40 Ligand, gp39, TRAP Mediates B-cell proliferation, IgE production and is involved in immunoglobulin class switching
CD155 PVR, NECL-5 Mediates NK cell adhesion and triggers their effector functions.
CD156a ADAM8 Possible involvement in extravasation of leukocytes
CD156b ADAM17, ADAM18, CSVP, NISBD, NISBD1, TACE Cleaves transmembrane form of TNF-α to generate the soluble active form.
CD156c ADAM10 Metalloprotease activity, cleaves many proteins including TNF-α and E-cadherin
CD157 BST-1 Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth
CD158a p58.1, KIR2DL1 Inhibits the activity of NK cells
CD158b2 NKAT-2, KIR2DL3 Inhibits the activity of NK cells
CD158d KIR2DL4, KIR-103AS Inhibits the activity of NK cells
CD158e KIR3DL1 Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158z KIR3DL3 Inhibits the activity of NK cells
CD159a NKG2A, KLRC1, NKG2 Negative regulation of NK cell activation
CD160 BY55, NK1 Broad specificity receptor for MHC class I molecules
CD161 NKR-P1A, KLRB1 Inhibits NK cell mediated cytotoxicity. Induces immature thymocyte proliferation
CD162 PSGL-1, SELPLG Mediates rapid rolling of leukocytes over vascular surfaces during inflammation
CD163 M130, MM130 Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages.
CD164 MGC-24, MUC-24
Facilitates the adhesion of CD34+ cells to the stroma and negatively regulates their proliferation
CD166 ALCAM Mediates cell adhesion by binding to CD6 for intrathymic T-cell development
CD167a DDR1, MCK10 Receptor tyrosine kinase involved in cell-cell interactions
CD167b DDR2 Receptor tyrosine kinase involved in cell-cell interactions
CD170 Siglec-5, CD33-like2, SIGLEC5, OB-BP2 Adhesion molecule mediating sialic-acid dependent binding to cells
CD171 NCAM-L1, L1CAM Multidomain cell adhesion molecule required for normal neurohistogenesis
CD172a SIRPα, SHPS-1, SIRPA Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172b SIRPβ, SIRB1 Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172g SIRPγ, SIRPB2 Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47
CD176 Thomson Friedrenreich Ag, TRF1, TRF Potentially involved in cell adhesion
CD177 NB1 glycoprotein, HNA-2a Major immunogenic molecule of neutrophil membrane
CD178 FasL, CD95L, FASLG, Fas Ligand T-cell mediated cytotoxicity
CD179b IGLL1 Early B-cell differentiation.
CD180 RP-105 Controls B-cell recognition and signaling of LPS. Leads to NFkB activation.
CD183 CXCR3 T-cell chemotaxis, integrin activation, and adhesion
CD185 CXCR5, BLR1 Homing and cell movement
CD186 CXCR6, BONZO, STRL33, TYMSTR B-cell development
CD191 CCR1, MIP-1αR, RANTES-R Chemotaxis, adhesion
CD192 CCR2, MCP-1-R Leukocyte chemotaxis and is an HIV co-receptor
CD196 CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis.
CD200 OX-2, OX2 Down-regulatory signal for myeloid cell function, costimulates T-cell proliferation
CD 201-250
Name Alias Function
CD201 EPC-R, PROCR Enhances protein C activation
CD202b Tie2, Tek Signaling, migration and adhesion
CD204 Macrophage scavenger-R, MSR1 Endocytosis of macromolecules including low density lipoproteins, host defense
CD205 DEC-205, LY75 Phagocytosis, endocytosis
CD207 Langerin Pathogen receptor and processing of antigen for presentation to T-cells
CD208 DC-LAMP, LAMP3 Dendritic cell maturation marker, involved in cell proliferation
CD209 DC-SIGN Mediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120
CD212 IL-12-R β1, IL12RB1 Forms part of the receptor complexes for IL12 and IL23
CD213a1 IL-13-R α1, IL13RA1 Forms part of the receptor complexes for IL13 and IL4
CD213a2 IL-13-R α2, IL13RA2 Forms part of the receptor complex for IL13.
CD215 IL15RA Receptor for IL15.
CD217 IL-17R, IL17RA Receptor for IL17A and IL17F
CD218a IL-18Rα, IL-1Rrp, IL18R1 Forms part of the receptor complex for IL18
CD218b IL-18Rβ, IL18RAP Forms part of the receptor complex for IL18
CD220 Insulin-R, Insulin Receptor, IINSR Insulin receptor
CD221 IGF-1 R, IGF1R Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD223 LAG-3 Involved in lymphocyte activation, negative regulation of T-cell activation
CD224 GGT1 Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis.
CD225 IFITM1, Leu-13, DSPA2a Cell adhesion, cell growth and migration. Relays antiproliferative and homotypic adhesion signals
CD226 DNAM-1, PTA-1, TLiSA1
Intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells
CD227 MUC1, EMA, PUM, Mucin 1 Cell adhesion and signaling
CD228 Melanotransferrin, MFI2 Involved in cellular iron uptake
CD229 Ly-9, LY9, SLAMF3 Adhesion between T-cells and accessory cells
CD230 Prion protein, PRNP Oxidative stress homeostasis,cell survival, and signal transduction
CD231 TALLA-1, A15, Tspan-7, Cell proliferation and motility
CD233 Band 3, SLC4A1 Anion exchanger across the cytoplasmic membrane, binding site for cytoskeletal proteins, enzymes and hemoglobin
CD235a Glycophorin A, GYPA Major erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation, receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus
CD236 Glycophorin C/D, GYPC Glycophorin-C regulates the stability of red cells
CD238 Kell, KEL, Blood Group Kell Zinc endopeptidase cleaving endothelin 3. Contains the Kell blood group antigens
CD239 B-CAM, BCAM Laminin alpha-5 receptor
CD242 ICAM-4 Ligand for the leukocyte adhesion protein LFA-1
CD244 2B4, NAIL NK cell activation, NK cell and T-cell interaction
CD247 TCRz, CD3-ZEETA Couples antigen recognition to several intracellular signaling pathways
CD249 Aminopeptidase AM, EAP, ENPEP Converts angiotensin II to angiotensin III.
CD 251-300
Name Alias Function
CD252 OX40L, gp34 Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
CD253 TRAIL, Apo-2L, TL2, TNFSF10 Induces cell death by apoptosis
CD254 TNFSF11, RANKL, OPGL, ODF Involved in dendritic cell maturation
CD256 APRIL, TALL-2, TRDL-1, TNFSF13 Important for B cell development
CD257 BLyS, BAFF, TALL-1, TNFSF13B Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity
CD258 LIGHT, HVEM-L, TNFRSF14 Stimulates T-cell proliferation, receptor for Herpes simplex virus
CD261 TRAIL-R1, DR4, TNFRSF10A Induces apoptosis, promotes activation of NFkB
CD262 TRAIL-R2, DR5, TNFRSF10B Activated by TNFSF10 / TRAIL and transduces apoptosis signal
CD264 DCR2, TRAIL-R4, TNFRSF10D Receptor for TRAIL, inhibits apoptosis
CD265 RANK, TRANCE-R, ODFR, TNFRSF11A Receptor for TRANCE. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis
CD266 TWEAK-R, FGF-inducible 14, TNFRSF12A Receptor for TWEAK. Promotes angiogenesis and the proliferation of endothelial cells.
CD267 TACI, TNFR SF13B, TNFRSF13B Receptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB.
CD268 BAFFR, TR13C,TNFRSF13C B-cell receptor for CD257. B-cell response
CD269 BCMA, TNFRSF13B, TNFRSF17 Receptor for CD256 and CD257, activates NFkB and JNK.
CD270 HveA, TR2, TNFRSF14 Receptor for CD258 and CD272.
CD271 NGFR, p75 (NTR) Regulates neuronal growth, migration, differentiation and cell death during stem cells.
CD272 BTLA Lymphocyte inhibitory receptor
CD273 B7DC, PD-L2, PDCD1L2 Stimulatory on dendritic cells, inhibits T-cell activation upon engaging the PD1 receptor.
CD274 B7-H1, PD-L1 Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition
CD275 B7-H2, ICOSL, B7-RP1, GL50
Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation
CD276 B7-H3 Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling
CD277 BTN3A1, butyrophilin SF3 A1, BTF5 T-cell activation
CD278 ICOS, AILIM Mediate cell-cell interactions, and effective help for antibody secretion by B-cells
CD279 PD1, SLEB2 Inhibitory cell surface receptor involved in T-cell tolerance
CD281 TLR1 Pathogen recognition and activation of innate immunity, regulates TLR2 function
CD282 TLR2 Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB
CD283 TLR3 Mediator of innate immunity against viral infection, activated by dsDNA
CD284 TLR4 Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons
CD286 TLR6 Receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins
CD292 BMPR1A, ALK3, SKR5 Receptor for BMP-2 and BMP-4
CD295 LeptinR, LEPR, OB-R, Leptin Receptor Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis
CD296 ART1,ARTC1 Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins
CD297 ART4, dombrock blood group Plays a role in the metabolism of Dombrock blood group antigen
CD298 ATP1B3, ATPB-3 Component of Na+-K+ pump on neuronal membranes.
CD299 DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M, DC-SIGNR Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus
CD300a CMRF35H, IRC1, IRp60M, CLM-8 NK cell function; also suppresses the effects of eotaxin, IL-5 and GM-CSF on neutrophils; and inhibits Ig-E dependent
CD300b CLM-7, IREM3, LMIR5, CMRF35-A2 Activating immune receptor by interaction with TYROBP
CD300c CMRF35A, LIR, CLM-6 Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells
CD300e CMRF35L, CLM-2, CMRF35-A5 Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules
CD300f CLM-1, IREM-1, LMIR3 Inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation
CD300g CLM-9, TREM4 May mediate L-selectin-dependent lymphocyte rollings
CD 301-
Name Alias Function
CD301 MGL, HML, CLEC10A, MGL1 Cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding
CD302 DCL1, BIMLEC Cell adhesion and migration
CD304 BDCA4, neuropilin 1, CLEC4C, NRP1 Angiogensis, axon guidance, cell survival, migration, and invasion
CD305 LAIR1 Negative regulator of NK, B, and T cells
CD306 LAIR2 Inhibits cellular activation and inflammation
CD307 IRTA2, FCRL5 May function in B-cells activation and differentiation
CD307a FCRL1 May function in B-cells activation and differentiation.
CD307b FCRL2 May function in B-cells activation and differentiation.
CD309 VEGFR2, KDR, FLK-1 Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD314 NKG2D, KLRK1 Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
CD315 PTGFRN, CD9P-1, EWI-F, FPRP, SMAP-6 Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor.
CD316 EWI2, PGRL, CD81P3, KASP,IGSF8, EWI-2, KCT-4 Negative regulator of cell motility.
CD317 BST2, HM1.24 IFN-induced antiviral host restriction factor
CD318 CDCP1, SIMA135 Cell differentiation, homing and dissemination. May also have a pro-survival role
CD319 CRACC, SLAMF7 Mediates NK cell activation and may play a role in lymphocyte adhesion
CD320 FDC-SM-8D6, TCbIR, 8D6 antigen Augments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin
CD321 JAM-A, JAM-1, PAM-1, F11R Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD322 JAM-B, JAM-2, VE-JAM May play a role in lymphocyte homing to secondary lymphoid organs
CD324 E-Cadherin, Uvomorulin, CDH1, E-cad Calcium-dependent cell adhesion protein
CD325 N-Cadherin, NCAD, CDH2
In hippocampal cells, pancreatic cells and hepatocytes
CD326 Ep-CAM, Ly74,, EGP314, TROP-1, TACSTD1 A homotypic calcium-independent T-cell adhesion molecule
CD327 SIGLEC6, OB-BP1 Adhesion molecule that mediates sialic-acid dependent binding to cells
CD331 FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM Receptor for basic fibroblast growth factor.
CD332 FGFR2, BEK, KGFR Cell-surface receptor for fibroblast growth factors
CD333 FGFR3, ACH, CEK2 Cell-surface receptor for fibroblast growth factors
CD334 FGFR4, JTK2, TKF Cell-surface receptor for fibroblast growth factors
CD336 NKp44, Ly-95 homolog, NCR2 Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis
CD337 NKp30, Ly117, NCR3 Cytotoxicity-activating receptor that contributes to the increased efficiency ofactivated NK cells to mediate tumor cell lysis
CD338 ABCG2, BCRP, Bcrp1, MXR Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain and cancer cells
CD339 Jagged-1, JAG1, JAGL1, hJ1 Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development
CD340 ERBB2, MLN 19 Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways
CD344 Frizzled-4, Fz-4, FzD4 Receptor for Wnt proteins
CD350 Frizzled-10, Fz-10, FZD10 Receptor for Wnt proteins
CD352 NTB-A, SLAMF6, LY108 Triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors
CD353 SLAMF8 Regulates macrophage function; may play a role in B cell lineage commitment
CD354 TREM-1 Stimulates neutrophil and monocyte-mediated inflammatory responses.Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers
CD355 CRTAM Interaction with CADM1 promotes NK cell cytotoxicity and IFN-gamma secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo
CD357 TNFRSF18, GITR Receptor for TNFSF18
CD358 TNFRSF21 May activate NFkB and promote apoptosis. May activate JNK and be lymphocytes. involved in T-cell differentiation. Required for both normal cell body death and axonal pruning
CD360 IL-21R Receptor for interleukin-21.
CD362 Syndecan-2, HSPG, SDC2 Cell surface proteoglycan that bears heparan sulfate
CD351 FCAMR, Fcα/μR Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity
CD365 HAVCR1, HAVCR, KIM-1, TIM, TIM-1, TIMD1 as a stimulatory molecule for T-cell activation
CD366 TIM-3, TIMD3 T-cell exhaustion, immune checkpoint
CD367 DCIR, DDB27, CLECSF6, CLEC4A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD368 MCL, CLECSF8, CLEC-6, MPCL, CLEC4D cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD369 DECTIN-1, CLECSF12, CLEC7A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD370 HEEE9341, UNQ9341, DNGR1, CLEC9A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD371 CLL-1, MICL, DCAL-2, CLEC12A cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response

Cluster of differentiation

The cluster of differentiation (or cluster of designation), often abbreviated as CD, is a protocol used for the identification and investigation of cell surface molecules present on white blood cells (cells of the immune system). The cluster of differentiation nomenclature was proposed for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes. Since then, the use of cluster of differentiation has expanded to many other cell types, and for humans CD is numbered up to 350 most recently (as of 2009)

The human cluster of differentiation (CD) antigens constitute a promising assay content for antibody microarray applications, because of their common expression at the leukocyte cell surface and the fact that the majority perform critical functions in the human immune response. The diagnostic potential of a microarray, containing 82 cluster of differentiation monoclonal antibodies (DotScan microarrays) has been demonstrated for a variety of infectious and neoplastic disease states, including HIV, many acute and chronic leukemias, and colorectal cancer. It is likely that these cluster of differentiation monoclonal antibody microarrays will have more general utility that extends to other pathological categories, including autoimmune, metabolic, and degenerative diseases.

Cluster of differentiation antigens are not merely markers on the cell surface. Cluster of differentiation antigens can act in numerous ways and are important for immune reactions of organisms. They often act as receptors or ligands important to the cell, initiating a signal cascade and altering the behavior of the cell. Some cluster of differentiation antigens do not play a role in cell signaling, but have other functions, such as cell adhesion.

CD Antigen References

Zola H, et al. (2005) CD molecules 2005: human cell differentiation molecules. Blood. 106(9):3123-6.
Woolfson A, et al. (2006) The application of CD antigen proteomics to pharmacogenomics. Pharmacogenomics 7(5):759-71.
Ellmark P, et al. (2008) The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease. Methods Mol Biol. 439:199-209.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Lal S, et al. (2009) Using antibody arrays to detect microparticles from acute coronary syndrome patients based on cluster of differentiation (CD) antigen expression. Mol Cell Proteomics. 8(4):799-804.