Anti-SLAM / CD150 Antibody

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Anti-SLAM / CD150 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-SLAM / CD150 Antibody
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human SLAM / CD150
No cross-reactivity in ELISA with
Human CD48 / BCM1 / BLAST1
Human CD84 / SLAMF5
Human 2B4 / NKR2B4 / CD244
免疫原
Recombinant Human CD150 protein (Catalog#10837-H08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human SLAMF1 / CD150 (rh SLAMF1; Catalog#10837-H08H; NP_003028.1; Met 1-Pro 258).
来源
Monoclonal Rabbit IgG Clone #8
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SLAM / CD150 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:1000-1:4000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SLAM / CD150 Antibody (Rabbit Monoclonal 抗体) 图片

Immunochemical staining of human SLAMF1 in human tonsil with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SLAMF1 in human lymph node with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SLAMF1 in human appendix with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).

Anti-SLAM / CD150 Antibody: 别称

Anti-CD150 Antibody; Anti-CDw150 Antibody; Anti-SLAM Antibody

SLAM / CD150 背景信息

CD15/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD15 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD15 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th phenotype, and inhibition of apoptosis in B cells. Furthermore, CD15 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.
全称
signaling lymphocytic activation molecule family member 1
参考文献
  • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
  • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
  • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
  • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
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